Abstract
Over the past decade, microRNA molecules have emerged as critical regulators in the expression and function of animal genomes. This review discusses the relationship between microRNA-mediated regulation and the robustness of biochemical networks that contain microRNAs. Most biochemical networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the network. MicroRNAs involved in network robustness may appear to be nonessential under favourable uniform conditions used in conventional laboratory experiments. However, the function of these molecules can be revealed under environmental and genetic perturbations. Recent advances have revealed unexpected features of microRNA organization in networks that help explain their promotion of robustness.
Accepted Version (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
