Abstract
Publisher Summary This chapter describes the regulation and mechanisms of enzymes, known as Glycosis, the stepwise degradation of glucose to pyruvate by way of fructose diphosphate found in almost all cells. The major features of the pathway are approximately the same through all life forms, suggesting the achievement of an optimal evolutionary state for this system prior to the evolution of most present-day cell types. It has been observed that five successive enzymes of glycolysis (enzymes V–X) occur in constant activity relation to one another in a wide variety of tissues of the rat, rabbit, and cow, various muscle types of the locust, and in yeast, despite large change in their absolute content from tissue to tissue. These activity ratios correspond approximately to the turnover numbers of the five enzymes, suggesting that at least these glycolytic enzymes are produced and degraded in a coordinate fashion on a molecular basis.
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