Abstract
The use of matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) methodology can be considered a revolution in clinical microbiology laboratories. In addition to microbial identification, this technology can also be used to analyze clinical specimens such as blood, urine, and cerebrospinal fluid (CSF) for direct bacterial identification. The major limitation is the amount of bacteria present in the samples and the limit of detection of current MALDI-TOF protocols. Bacterial identification from CSF is strongly limited by the low bacterial load and the limited volume available, so it is yet not applicable in routine diagnostic laboratories. Moreover, there are very few reports describing the use of MALDI-TOF MS for the direct detection of microorganisms causing bacterial meningitis.
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