Abstract
Two distinct forms of rabies, furious and paralytic, are recognized in humans. The paralytic or atypical form of rabies poses a diagnostic dilemma because it is often clinically indistinguishable from Guillain-Barre syndrome (GBS). Immune complexes are present in several viral and bacterial human infections, and their presence has been utilized as a diagnostic marker. Detection of rabies-specific immune complexes in cerebrospinal fluid (CSF) can be utilized as a diagnostic test for antemortem diagnosis of paralytic rabies in humans. A capture ELISA that uses murine monoclonal antibodies (MAbs) to rabies nucleoprotein (N) and glycoprotein (G) to capture the respective antigen component of immune complexes has been developed and evaluated. This simple, rapid procedure capable of providing results within a few hours has been found to be 76.6% sensitive and 100% specific for detection of specific immune complexes in the CSF of patients with paralytic rabies.
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