Abstract
Preventive rabies vaccination of domestic and wild carnivores is the most successful measure to prevent and control rabies in countries where rabies is endemic. The World Health Organization (WHO), World Organization for Animal Health (OIE), and European Commission consider this vaccination to be valid when the neutralizing antibody titer is equal to or above 0.5IU/mL in the serum of vaccinated animals and humans. Neutralizing antibodies are known to be the most reliable indicator of successful vaccination to ensure satisfactory protection against rabies. Currently, to measure the neutralizing antibody level in a serum sample for international trade, the fluorescent antibody virus neutralization (FAVN) test is one of the two reference methods (the other is the Rapid Fluorescent Focus Inhibition Test, RFFIT), which are recognized and prescribed by WHO and OIE. This method is based on the principle of an in vitro serum neutralization of the live rabies virus in sensitive cells. Results obtained by this method are reliable and valuable.
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