Abstract
This chapter reviews knowledge on immunology of experimental hepatic tumours induced by chemical carcinogens, particularly with regard to the nature and characteristics of tumour-associated antigens. It is clear that hepatic tumours express antigens which are not detectable in normal tissues of the adult. These may differ in type, qualitatively or quantitatively, with the particular tumour model employed, although it is noteworthy that tumour-associated embryonic antigens are the most consistently expressed. No correlation has emerged between the occurrence of these antigens and the tumour rejection and cell surface antigens. However, as indicated in Section 9.5, individually distinct neoantigens have been demonstrated on cells transformed in vitro, suggesting the possibility that similar assays of neoantigen profiles upon normal cells treated with chemical carcinogens may provide relatively rapid screening assays for the detection of neoplastic transformation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
