Abstract
The mechanics of dry-powder inhalers (DPIs) is considered from a fundamental perspective. Basic aspects of DPIs are given, followed by a detailed examination of the origin of adhesion forces between powder particles. The effect of surface roughness on adhesion, including models for predicting adhesive forces between rough particles, is discussed. The effect of capillary condensation of water and recent perspectives on the effect of electrostatic charge on adhesive forces are considered. Aerodynamic forces during powder entrainment and recent models for predicting these forces are given. Turbulence and its ability to detach agglomerated particles by direct aerodynamic forces and by transient accelerations induced by eddies are examined. Particle detachment by impaction, collision, and vibration is considered, followed by a discussion of dry-powder inhaler design.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.