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Abstract
This chapter discusses the control of rod disk membrane (RDM) phosphodiesterase (PDE) and a model for visual transduction. The transduction of single-photon absorptions into the closure of Na + channels and a change in membrane potential that serves vision in vertebrate rods have a number of characteristic properties that must be understood in terms of their underlying biochemistry and biophysics. The chapter discusses kinetic evidence from the laboratory that leads to a different model of visual transduction in which the diffusional interaction of rhodopsin with other enzymes on the surface of the RDM provides the earliest and rate-limiting steps of this process. The final stage of the model involves Ca 2+ , but all of the control of gain, speed, and sensitivity originates in the modulation of the cytoplasmic cyclic guanosine 3´,3´-monophosphate (cGMP) concentration.
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