Abstract
Colloostatin is an oostatic factor isolated from the ovaries of the gray flesh fly Neobellieria bullata. It consists of 19 amino acids (H–Ser–Ile–Val–Pro–Leu–Gly–Leu–Pro–Val–Pro–Ile–Gly–Pro–Ile–Val–Val–Gly–Pro–Arg–OH), and the name is derived from structural sequence similarities with parts of several known collagens and its oostatic activity. Colloostatin inhibits yolk uptake by previtellogenic oocytes in N. bullata but does not inhibit trypsin biosynthesis in the gut or ecdysone biosynthesis by larval ring glands, in contrast to trypsin-modulating oostatic factors (TMOFs).
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