Abstract
Eosinophil-associated gastrointestinal disorders (EGID) are a group of related disorders characterized by gastrointestinal (GI) symptoms and eosinophilic infiltration of the gastrointestinal wall. The two major forms of EGID, eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), differ in regard to the site of inflammation (esophagus vs. stomach/small bowel). Since 1995, EGID and in particular EoE have been increasingly recognized as important clinical entities. Both EoE and EGE are highly associated with coexisting allergic disease, and a large fraction of EGID patients are sensitized to multiple food allergens. Existing data strongly support the concept that EGID is a food-allergen driven eosinophilic inflammatory gut disease. As such, EGID is the most well-defined allergic inflammatory gut disease and is a tractable system for understanding the genesis of allergic gut inflammation.
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