Abstract
Aging is the most important risk factor for the vast majority of chronic conditions that lead to disability and death, and account for the bulk of heath care costs in developed countries. Translational research in aging has the potential to influence not only life span, but health span—the number of years one spends in health, free from disease, or disability. Animal models and human cohorts are useful in translational research in aging, but important limitations exist and influence experimental design, interpretation of results, and generalizability of findings. These issues are discussed in this chapter with specific examples of translation from yeast to rodents to humans to populations, and a number of resources available to assist translational research in aging are outlined.
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