Abstract
Tendons are crucial components of our musculoskeletal system capable of withstanding and transmitting forces. Injuries to tendons result in pain and limited mobility and are widespread problems for a significant portion of the population. Unfortunately, tendon healing is slow and inefficient, and the tissue never regains its original properties. Surgical intervention can improve mobility after injury, but these treatments often can result in failure and limited tendon function. Regenerative medicine approaches using stem cells is a promising research area that can facilitate the development of new clinical therapies for tendon injuries. In applying these approaches to the tendon, it is important to have a comprehensive understanding of tendon development, maturation, and healing. In this chapter, we will review our understanding of tendon biology and place it in the context of current stem cell approaches.
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