Abstract
Mice have been commonly used for different purposes in a variety of preclinical studies, mainly because of the availability of a wide range of disease models as well as genetically altered animals. It is, however, necessary to develop elemental technology that is optimized for mouse-specific measurements to achieve a successful outcome from magnetic resonance (MR) studies using hyperpolarized (HP) noble gases (e.g., 129Xe and 3He). In this chapter, we provide a brief overview of the recent progress made by our group in the development of HP 129Xe MR measurements at 9.4 Tesla. Our research focuses on HP 129Xe MR spectroscopy and imaging in mice that spontaneously inhale the HP 129Xe continuously delivered from a hyperpolarizer. This simple and noninvasive protocol allows us to perform HP 129Xe MR studies in mice under natural physiological conditions. Some successful examples of this protocol are summarized in assessing physiological conditions related to pulmonary functions.
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