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Abstract
Publisher Summary This chapter discusses brain dialysis of monoamines. Brain dialysis was first applied to the estimation of extracellular concentrations of amino acids and the first systematic studies utilizing this methodology focused on monoamines, particularly, on dopamine. Although brain dialysis is now being applied to the estimation of the extracellular concentrations of virtually all classes of neurotransmitters and neuromodulators, studies on monoamines still form the bulk of the overall production with this technique. The reasons for the early attraction between monoamines and brain dialysis are various but can be reduced to at least two major ones: (1) the appealing possibility that the technique of brain dialysis would solve many open issues in the monoamine field in the late 70s; (2) the possibility of applying, by virtue of the electroactive nature of monoamines, the newly developed technique of high pressure liquid chromatography (HPLC) with electrochemical detection, thus, enabling the on line measurement of the low amounts of transmitter present in dialysates. These reasons are still operative in supporting a continuing relationship between brain dialysis and monoamines.
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