Chapter 8 - Anticoagulant Agents

Abstract

At first coumarin was recognized as an anticoagulating agent. At the C3 position, the presence of acetoxy groups, amine groups substituted with phenyl rings, and pyridine rings bearing nitrogen atoms at the 2′ position and a chlorine atom at the 3′ position was effective in inhibition of thrombin (THR). At C7, C4, and C2 positions, hydroxyl substituents are effective. At the C4 position, beta-enaminone or piperazinyl groups are effective. At the C7 position, propoxy, butoxy groups are effective, and at the C8 position it is methyl groups.