Abstract
At first coumarin was recognized as an anticoagulating agent. At the C3 position, the presence of acetoxy groups, amine groups substituted with phenyl rings, and pyridine rings bearing nitrogen atoms at the 2′ position and a chlorine atom at the 3′ position was effective in inhibition of thrombin (THR). At C7, C4, and C2 positions, hydroxyl substituents are effective. At the C4 position, beta-enaminone or piperazinyl groups are effective. At the C7 position, propoxy, butoxy groups are effective, and at the C8 position it is methyl groups.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Advances in Structure and Activity Relationship of Coumarin Derivatives
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
