Abstract
Publisher Summary This chapter describes the clinical studies using autologous adrenal medulla grafts to the head of the caudate nucleus in patients with severe parkinsonism. The chapter aims to provide the striatum with a new cellular source of catecholamines (CA). The patients with severe Parkinsonism studied in this chapter are significantly better after autologous adrenal medullary tissue transplantation in comparison with their preoperative performance. Akinesia, rigidity, and tremor are improved and as a result, the patients experience an increased ability to carry out their activities of daily life. The chapter provides evidence for grafts surviving and secreting DA including (1) the surplus adrenal medullary tissue contains large quantities of catecholamines, and (2) the levels of cerebrospinal fluid (CSF) dopamine (DA) show pronounced elevation after surgery. The average level of postoperative DA was two to three times greater than that before operation. Studies are underway for characterizing the important factors for functional recovery using adrenal transplants into the striatum.
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