Abstract
This chapter discusses the grafting potential of human fetal adrenal tissue with the recognition of the high growth potential and functional plasticity of the tissue, when compared to the adult tissue and by the data expressed in the literature that favors the use of young or fetal tissue donors. The in vitro models studied provide a convenient method for expeditiously assessing the potential of human fetal adrenal medullary tissue for grafting in the parkinsonian patients. The results show that human fetal adrenal medullary cells can be isolated and grown in vitro to identify their essential nutritional requirements. Fetal human adrenal medullary cells do not seem to need nerve growth factor (NGF) for process formation and neuronal phenotype expression, while adult human adrenal medullary cells are more resistant to the enzymatic dissociation and require NGF for neurite extension in culture. The viability of cultured human fetal chromaffin cells in media with 10% cerebrospinal fluid (CSF) suggests that placing a graft in the periventricular or intraventricular regions may guarantee the growth and survival of the transplant.
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