Abstract
• TBE often takes a severe clinical course in immuno-supressed patients. • In transplant patients TBE usually takes a fatal course. • TBE vaccination in immuno-suppressed patients can be non-effective • TBE in pregnancy has been rarely reported; from recent cases there is no evidence of transplacental infection of the offspring. • The alimentary route of infection of TBE is still common in some European countries resulting in a high clinical manifestation index. • TBEV can be infectious in milk and milk products for up to 14 days under optimal environmental conditions. • TBE is an important travel-related disease. Increasing numbers of non-endemic countries report imported cases. • Imported TBE cases in non-endemic areas pose challenges regarding the diagnosis of TBE.
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