Abstract
Post-transcriptional gene regulation facilitates an elaborate and distinct set of procedures to manipulate RNA for maturation, stability, expression, transport, and translation. High-throughput screenings of human samples have given an insight into gene mutations and expression signatures underlying various metabolic diseases. Gene dysregulation is at the heart of carcinogenesis. Understanding the tuning of post-transcriptional regulation in cancer will not only add to our current knowledge of the disease but also will pave the way to formulate clinical tactics to diagnose, predict, and treat better. This chapter is an overview of the basics of post-transcriptional gene regulation and its manipulation in selected solid tumors accounted as being associated with poor prognosis and survival. We discuss here the fine regulators of post-transcriptional control in the expression of genes associated with key pathways involved in the development of solid tumors. Also reviewed are the therapeutic agents in clinical trials to target the regulatory machinery of post-transcriptional events in cancer.
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