Abstract
For cancer management, diverse nanosystems have been designed and evaluated as drug carriers. Poly(lactic-co-glycolic) acid (PLGA) is one such material that has been extensively used to develop biomedical nanoparticles. The biocompatibility, biodegradability, and high mechanical strength of PLGA give it advantages over other materials. This chapter gives an overview of synthesis methods of PLGA, its properties, and its applications in cancer diagnosis and therapy. This is elaborated through strategies to employ PLGA nanoparticles for diagnosis and imaging in cancer. Subsequently, applications of PLGA in drug loading and cancer treatment are discussed. Here, the emphasis is on how different drug-loaded PLGA can be employed to target oncogenes, metastasis, angiogenesis, tumor immune checkpoints, and therapy resistance. Additionally, PLGA nanoparticles as theranostic agents have been briefly mentioned. The review essentially puts forward the great potential of PLGA-based nanosystems in cancer management.
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