Abstract

Publisher Summary This chapter discusses lead (Pb) exposure in human populations. Exposure refers to actual contact with lead in one or more environmental media by human populations. It also refers to both intake of media lead into various receiving body compartments and subsequent uptake into the human body. Two processes in human lead exposures are described, that is, lead intake and lead uptake. Lead uptake deals with lead absorption into the bloodstream from receiving body compartments. Lead intake by inhalation occurs in two stages: (1) some fraction of inhaled lead is retained and deposited in various compartments of the respiratory tract and (2) the balance is exhaled. The chapter serves as the toxicological interface between lead in the external environment and lead in the human body. Lead-containing environmental media ingestion or inhalation rates are presented for ambient air, diverse human diets, drinking water, and dust and/or soil. Various primary sources for estimating the exposure parameters associated with daily intake quantities of lead-containing media are used and noted.

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