Abstract
Energy metabolism refers to all the reactions involved in generating adenosine triphosphate (ATP) from nutrients, including both aerobic respiration (oxygen present), anaerobic respiration (fermentation) as well as fatty acid and amino acid metabolism. Under normoxic conditions, normal cells use aerobic respiration to oxidize glucose via mitochondrial oxidative phosphorylation. Cancer cells, on the other hand, prefer to ferment glucose into lactate even with oxygen present (Warburg effect) and show altered lipid and amino acid metabolism. This chapter discusses the metabolic features of neuroblastoma (NB), which enable the tumor to maintain the ATP levels and biomass necessary for supporting high proliferation and highlights new metabolic targets in NB therapy.
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