Abstract
Various liver function tests (LFT) are widely used to evaluate hepatic or biliary diseases as a part of the routine laboratory testing. Abnormal LFT have been reported to be observed in acute or chronic heart failure (HF) patients, and these abnormalities are generally considered as an end-organ damage as a consequence of altered hepatic metabolism in HF patients. LFT observed in HF patients are divided into three different types (1) markers of hepatocellular injury or hepatocellular necrosis (transaminases), (2) markers reflective of obstructive or cholestatic disease (hepatobiliary markers), and (3) markers of impaired hepatic protein synthesis function and hepatic fibrosis markers. This chapter will focus on the anatomy and metabolism in the hepatocytes and the liver, the pathophysiology of abnormal LFT in HF, and the role of hepatic fibrosis markers in HF. This chapter will also focus on liver function test abnormalities and its impact on prognosis in HF patients.
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