Chapter 7 - Animal models of primary brain tumors

Abstract

Animal models have played a key role in elucidating the mechanisms underlying the occurrence, recurrence, and therapeutic treatment of primary brain tumors. In this chapter, we review the various types of human primary brain tumors, describe the general properties of the dominantly used animal model systems, and propose general guidelines to help optimize animal model creation. We also discuss the history and current uses of rodent models in the study of the pathologenesis and treatment of various important types of primary brain tumors, including adult and pediatric glioma, meningioma, medulloblastoma, and CNS lymphoma. Included is an analysis of the role of rodent models in the development of immune-based therapies for brain tumors. Lastly, we summarize the tradeoffs and limitations of currently existing animal models of primary brain tumors and discuss the current outlook for future developments.