Abstract
Publisher Summary This chapter describes the neurochemical correlates of behavioral changes by measuring concentrations of monoamine metabolites in cerebral spinal fluid (CSF) using microdialysis in freely moving rats before and after intraventricular grafts of adrenal medulla or control tissue. The data indicates that adrenal medulla grafts in the lateral ventricle induce a change in dopaminergic activity in vivo. Dopamine (DA) turnover is increased in animals with adrenal medulla grafts indicated by: (1) an increase in CSF concentrations of dihydroxyphenylacetic acid (DOPAC), (2) a greater response to amphetamine sulfate (AMPH), and (3) a greater rate of DA metabolite accumulation following probenecid. If an adrenal medulla graft is effective in reducing AMPH-stimulated rotational behavior, then the concentrations of DA in the striatum adjacent to the graft are significantly elevated compared to control animals and relative to the graft. This increase in striatal DA concentrations reflects an increase in the functional capacity of striatal DA neurons is supported by preliminary findings that AMPH stimulates DA release from the striatum of animals with adrenal medulla grafts, but not in animals with adrenal cortex grafts.
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