Abstract

The Epstein-Barr virus (EBV) is one of the herpes viruses that infect humans. Other members of this group include herpes simplex types I and II, varicella-zoster virus, cytomegalovirus, human herpes virus types 6, 7, and 8, and simian herpes B virus ( Herpes simiae ). The latter is primarily an infection of nonhuman primates, with humans as accidental hosts. Herpes viruses share some common characteristics. They all produce viral latency, meaning that the viral genetic material is integrated into that of the host. However, this does not mean that the virus is completely dormant because there is production and display of virus antigens of EBV on host cell surfaces. EBV is different from other human herpes viruses in that it has several distinct antigens that do not cross-react. These antigens provide unique serologic markers for EBV activity.

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