Abstract
The group of autoimmune bullous skin diseases encompasses a number of specific disorders in which an autoimmune response is directed against skin adhesion molecules leading to blister formation. These disorders can be divided into two general groups: pemphigus and pemphigoid. Broadly defined, the pemphigus group includes those diseases in which the blisters occur within the epidermis (intraepidermal blister formation). The pemphigoid group includes those diseases in which the blisters occur at the junction of the epidermis and dermis (subepidermal blister formation). Each specific disease has unique clinical and immunological features, antigenic targets, and pathophysiology. This chapter highlights the three most common autoimmune bullous skin diseases: pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid.
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