Abstract
A key factor in the development of high resolution 3 H nuclear magnetic resonance (NMR) spectroscopy of tritiated compounds in solution has been the use of a sealed sample assembly within the conventional NMR tube making it very unlikely that any radioactivity would be released even in the event of a tube breakage. Rapid molecular reorientation in the liquid state is the main reason that the intrinsic linewidths of solution NMR spectra are so narrow. In contrast, in most solids, molecular reorientation is not sufficiently fast to average the dipolar spin interactions and consequently, broad lines are obtained. These are usually narrowed by a combination of techniques—namely, magic-angle spinning, high power proton decoupling, cross-polarization and multiple pulse sequences. Low power proton decoupling has been used regularly to obtain 3 H NMR spectra of liquids but the small differences in the 1 H and 3 H frequencies pose a problem for the solid state. However, it is possible to obtain 3 H NMR spectra of solid tritiated compounds in a safe and routine manner.
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