Abstract
Kidney disease can result from insufficient functional nephron mass. Current treatment options are limited to dialysis and allograft organ transplant, which have significant limitations and side effects. Regenerative medicine approaches in which damaged kidneys in patients are supplemented with new nephrons could be a useful therapeutic strategy. Recent discoveries have differentiated human pluripotent stem cells into nephron-like structures, called human kidney organoids, which contain segments of podocytes, proximal tubules, and distal tubules along a proximal-to-distal axis. When transplanted into mice, kidney organoids recruit vasculature from the host to form glomerulus-like structures, and show signs of partial maturation. However, there is still a lack of information regarding the safety, maturity, and functionality of human kidney organoids as regenerative therapeutics. These issues must be addressed prior to clinical application.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
