Abstract
Bronchopulmonary dysplasia (BPD), a chronic lung disease that affects very premature infants receiving prolonged ventilator and oxygen therapy, is a major cause of mortality and long-term morbidity. Several preclinical and clinical studies have indicated that stem cell therapy is a promising novel therapeutic modality for preventing and/or treating BPD. This chapter will summarize the recent advances in stem cell research in the prevention and/or treatment of BPD, with particular focus on preclinical and clinical data relevant to critical issues essential to clinical translation, such as patient selection, optimal cell type, route, dose, and timing of stem cell transplantation.
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