Abstract
Abstract Since its introduction, the HMBC—Heteronuclear Multiple Bond Correlation—experiment has modernized NMR spectroscopy in small to medium molecule applications. The experiment provides information about which protons are near to different carbons or to another heteronucleus, but not directly bonded to. This experiment can provide a huge amount of information about molecular structure, since the long-range proton–carbon correlations can include quaternary carbons, in addition to protonated carbons. Impressive examples for structure elucidation of organic molecules, peptides, or natural products have been published in the last 20 years. After a short introduction into the basic theory, this manuscript will give to the reader an overview of the last developments and improvements of HMBC experiments, ranging from pulse sequences dedicated for suppressing one-bond correlations to HMBC pulse sequences that allow distinguishing between 2JCH and 3JCH cross-peaks.
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