Abstract
Strain improvement of industrial microorganisms plays a significant role in bioprocess development. The development of microbial strains with increased productivity/efficiency provides an opportunity for the overall cost reduction of the bioprocesses. Therefore continuous efforts are made to develop and improve the industrial strains. For instance, strains that can produce more titer of a desired enzyme/metabolite, and strains that can utilize low-cost substrates such as lignocellulosic biomass can make the industrial bioprocess economically viable. Conventionally, strain improvements were made using induced mutagenesis, followed by screening/selection strategies. During the 1980s, recombinant DNA technologies were used to develop microbial bioproducts. Genetically engineered microbes were also used to produce nonmicrobial bioproducts, such as insulin, growth hormones, and subunit vaccines. Subsequently, several molecular tools have been developed for strain improvement. This chapter describes the recent advancements in molecular tools for microbial strain improvement.
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