Abstract
Presented here is a background to the technology of Accelerator Mass Spectrometry (AMS) and its application as a supremely sensitive detector for analysis of radiocarbon (14C) label in drugs of interest. We highlight the wide variety of clinical study designs supported by AMS that deliver information on human absorption, distribution, metabolism, excretion, and pharmacokinetics (ADME-PK), including absolute bioavailability. The challenges and future opportunities for the application of AMS, including new generation instrumentation and alternative approaches in drug discovery and development are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
