Abstract
Epidermal growth factor (EGF) receptor localizes to low-density, cholesterol-enriched plasma membrane domains known as lipid rafts via an interaction that is mediated by its extracellular domain. Raft integrity appears to be important for the appropriate function and regulation of EGF-receptor-mediated signaling. Other receptor tyrosine kinases, including ErbB2, the PDGF receptor, the NGF receptor, and the insulin receptor, have been found to reside in or be recruited to lipid rafts. Disruption of rafts by depletion of cholesterol has been shown to modulate signaling mediated by many of these growth factors. Thus, lipid rafts appear to play a general role in the signaling function of receptor tyrosine kinases. This chapter describes what is known regarding the mechanism through which the EGF receptor is targeted to lipid rafts and discusses the role of localization to lipid rafts in EGF-receptor-mediated signaling.
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