Abstract
Publisher Summary This chapter reviews the major drug classes used to treat neuropathic pain and discuss an evidence-based treatment approach for the most common neuropathic pain conditions. The large number of clinical trials necessitate that referencing is restricted to important or major drug trials and reviews. The chapter discusses that a number of drugs have been shown to relieve neuropathic pain and their effect can be explained by their basic pharmacology. In both peripheral and central neuropathic pain, anticonvulsants or antidepressants are the first-line treatment, and the treatment of choice in trigeminal neuropathy is anticonvulsants. In clinical practice, pharmacological treatment of neuropathic pain deserves special attention with focus on drug contraindications and interactions as well as drug dosing and side effects to allow a specific drug treatment being successful. The chapter concludes that none of the pharmacological treatments relieve all patients of their neuropathic pain and even after several treatment options have been tried in succession, there will be a number of patients who cannot be relieved sufficiently with the current treatments. A search for new treatment options or combinations is needed.
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