Abstract
The SLC4 ( s o l ute c arrier 4) family is a group of a membrane proteins that share sequence homology and in general mediate the transport of bicarbonate. It should be noted that bicarbonate transport is not unique to the SLC4 family. The structurally unrelated SLC26 family has at least three proteins that mediate Cl − –HCO − 3 exchange. In this chapter, the biology of SLC4 Na + -dependent bicarbonate transporters will be highlighted. The outlier in the SLC4 family is the SLC4A11 gene product (NaBC1) that lacks the ability to transport bicarbonate and is currently characterized as an electrogenic sodium-borate transporter. Whether SLC4 transporters mediate bicarbonate and/or carbonate transport is unclear and therefore when the word bicarbonate or the chemical symbol HCO − 3 is used throughout the chapter with reference to SLC4 mediated ion transport, it refers to both HCO − 3 and/or CO 2− 3 .
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