Abstract
The cerebellum is important for regulating motor function and movement coordination, and more recently has been shown to regulate various behavioral functions, including cognition and communication of affection. Degeneration of the cerebellum and loss of Purkinje cells are the main causes for cerebellar ataxia, and dysfunctional Purkinje cells have also been associated in the development of autism. Purkinje cells are the sole output neurons of the cerebellum. Characterization of human Purkinje cell development is important for understanding the causes of cerebellar degeneration and neurodevelopmental disorders associated with Purkinje cell deficits.
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