Abstract
Publisher Summary This chapter discusses the calcium channel blockers and (merkel cells). The Merkel cell—neurite complex contains other ultrastructural characteristics that imply a neurosecretory function. Dense cored vesicles are seen concentrated around areas of the Merkel cell membrane that are closely apposed to the subjacent terminal, where they have also been seen to fuse. Three experimental procedures were used to test electrophysiologically the effect of cobalt chloride (CoC1 2 ), cadmium chloride (CdCl), and verapamil hydrochloride on the response of Sal mechanoreceptors to mechanical stimulation: (1) isolated hind limb perfusion in the cat, (2) intradermal injection under individual feline slowly adapting type 1 (SA1) mechanoreceptors, (3) isolated superfused rat skin nerve preparation. These results suggest that Ca 2+ is a necessary requirement for the normal function of Sal mechanoreceptors, possibly via the Merkel cell. This is further evidence supporting the concept of transmitter release from Merkel cells.
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