Abstract
Cutaneous drug reactions account for a large proportion of adverse drug reactions, can be very challenging to diagnose, and can mimic many other skin diseases. This chapter includes a review of general principles, mechanisms, and clinical manifestations of cutaneous drug eruptions. We have classified drug eruptions by morphology; exanthematous, urticarial, pustular, and bullous. Within each of these groups we have divided them into simple, benign or nonfebrile, and complex or febrile reactions. We also include a miscellaneous group to ensure a methodical review. Diagnostic maneuvers are discussed, and an algorithm is presented to enable the clinician to attain a reasonable level of diagnostic certainty about the responsible drug. Cutaneous drug eruptions can be important dermatologic signs of systemic disease.
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