Abstract
Blood safety has always been of major importance in transfusion medicine. To ensure safety, a combination of donor education, screening and testing for selected agents has been implemented. Pathogen reduction or inactivation is a proactive approach to reduce the occurrence of contaminating pathogens in the blood supply. Blood banks will require a technology that integrates into existing processing systems, and reduces the risk of transfusion-related infections virtually to zero. As measures to eliminate pathogens are generally evaluated in vitro as ‘log reduction’, and as it is difficult to prove the absence of transmission in clinical studies, the term ‘pathogen reduction’ to ‘pathogen inactivation’ is preferred and refers to reduction of infectious levels of agents that may be present in blood. Pathogen reduction technologies appear to hold great potential to help ensure that the blood supply is safe from blood-borne pathogens.
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