Abstract
This chapter deals with stem cell factor (SCF), which has been shown to be an essential growth factor in development, and maintenance of normal blood cell production. It synergizes with other hematopoietic growth factors to stimulate stem cells, primitive progenitor cells, and committed progenitor cells. Its clinical utility has been minimized by dose-limiting anaphylactoid reactions, however, clinical studies have demonstrated that in combination with granulocyte macrophage colony-stimulating factor (G-CSF), SCF can stimulate mobilization of increased numbers of CD34+ cells in peripheral blood progenitor cells (PBPC) products. If predictors of poor be a key growth factor for ex vivo manipulation of hematopoietic stem cells to produce regenerative tissues for various diseases mobilization can be developed. However, with the recent demonstration of plasticity of hematopoietic stem cells, generating cells of various tissues including, cardiac, neural, liver, lung, and endothelial cells. SCF may be a key growth factor for ex vivo manipulation of hematopoietic stem cells to produce regenerative tissues for various diseases.
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