Abstract
Royal Demolition Explosive (RDX) is a high-energy trinitramine compound. RDX can contaminate manufacturing or military sites where unexploded ordnance is found. Lethal dose (LD)50 values range from 70 to 200mg/kg/day for rodents. Oral or inhalation RDX doses provoked seizures in many species (e.g., humans, pigs, dogs, rodents, birds, and rabbits) that were correlated with RDX in the brain, and dissipated during bodily clearance of RDX. Seizures depended on gamma aminobutyric acid alpha (GABAA) inhibition in the brain. Chronic oral ingestion included decreased body weight, hematological, neurological, and hepatic effects. For class mammalia, BMD modeling of decreased body weight gain in rats derived Toxicity Reference Values of 1.19mg/kg/day (LED10) and 2.73mg/kg/day (Embryonic Day (ED10)). For the class averages, using decreased egg production in quail, the equivalent TRVs were 3.68 and 8.14mg/kg/day. For the class Reptilia, a LOAEL and NOAEL of 5 and 2.5mg/kg-day respectively were based on combined reduced food consumption and body weight. There was insufficient data to develop TRVs for amphibian classes.
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