Abstract
The c-JUN NH2-terminal kinase (JNK) pathway plays key roles in cellular proliferation and survival. Aberrant activation of the pathway occurs in multiple malignancies, where it contributes primarily to tumor growth. In addition, JNK pathway activation has been reported to promote resistance to anticancer agents. In this chapter, we will review current understanding of the involvement of the JNK pathway in tumor development and drug resistance. The identification and characterization of JNK pathway inhibitors will be described. Lastly, we will discuss the potential application of JNK inhibitors in human malignancies as a means of enhancing the effects of conventional chemotherapy drugs or overcoming resistance to these agents.
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