Abstract
Hyaluronan binding protein 1 (HABP1) is a ubiquitously present glycoprotein having specific affinity towards HA, originally purified from rat tissue. It has immunological cross-reactivity with human tissue, is used to identify the human homologue, and is located at human chromosome 17p13.3. Genomic organization and sequence analysis confirm its multifunctionality. Experimental evidence suggests the probable involvement of HABP1 in tumor development. It is shown to be an endogenous substrate of kinase and is involved in cell cycle regulation and apoptosis induction. A few physiological roles are proposed for HABP1 in macrophage cell adhesion: signal transduction, mammalian reproduction, and pathological infection on the basis of in vitro and in vivo experiments. Upon ectopic expression of HABP1 there is generation of excess ROS in the fibroblasts, creating intrinsic mitochondrial dysfunction along with induction of autophagic vacuoles and ultimately apoptosis. Finally, differential expression of HABP1 and loss of HABP1 in skin papilloma suggest its involvement in tumor initiation and promotion. Linkage analysis with different cancer patient samples also suggests the loss of heterozygosity of the human chromosome where HABP1 is located.
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