Abstract
Curcumin has an extensive history of medicinal use in different acute and chronic pathological conditions of the body. This polyphenolic compound has anti-inflammatory and antioxidant abilities, which might play a vital role in its beneficial effects in neurological disorders. Nevertheless, it has poor brain availability due to its faster metabolism by the liver and excretion by the kidneys. However, with the use of recent technology, its brain penetrability and effectiveness could be enhanced. Curcumin is safe to be administered at clinically relevant doses. However, there are not enough clinical studies to evaluate its effectiveness in neurological disorders. The clinical studies associated with the use of curcumin in Alzheimer’s disease have mixed outcomes. The present article outlines the effect of curcumin in neurological disorders, including Alzheimer’s, Parkinson’s, and migraine. Although not very potent, this naturally obtained molecule might be beneficial as an add-on therapy or in preventive care for neurological disorders.
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