Abstract
Autophagy is a cell correction process and impairment in it contributes to the development of cancer. Autophagy-related gene coded proteins contribute a role in the regulation of autophagic cellular loss. There are two ubiquitin-like conjugation systems are required for autophagy. Autophagy is a catabolic process that utilizes lysosomal degradation to recycle nutrients from damaged cell organelles and other cellular components. The involvement of various genes and their role is covered in this chapter. Various gene mutations are common in a variety of malignancies resulting in poor antigen presentation, immune evasion, and resistance to immunotherapy. The role of autophagy inhibitors in cancer treatment is covered. Many studies have established that the inhibition of autophagy can revoke drug resistance in cancer treatment. Various plant-derived natural constituents have recognizable anticancer potential. The common natural polyphenolic compound is resveratrol extracted from medicinal plants with proapoptotic effects on various cancer cells. In the present chapter, current research on autophagy control and its involvement in cancer genesis and treatment are highlighted.
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