Chapter 38 - Models of Seizures and Status Epilepticus Early in Life

Abstract

The use of animal models in experimental studies is responsible for much of our knowledge in epilepsy. The lack of appropriate animal models in the developing brain has led to a significant increase in research activity directed toward the development of newer models for childhood epilepsies. Animal models in the field of epilepsy are useful for a variety of purposes: investigation of pathophysiological mechanisms, evaluation and development of new treatments for seizures and epilepsies, and study of the consequences and treatments of conditions that may be concurrent with epilepsy (cognitive consequences and/or comorbidities). Various seizure models and status epilepticus (SE) models have been developed in the immature brain. These models are relevant for research purposes and they can provide information beyond epilepsy itself. In this chapter, we will focus on seizure and SE models in developing animals and their short-term consequences. After an introductory part on the challenges to work with young rodents, we will describe the seizure models, the SE models, and we will finish with the data on double hit injury models relevant to human conditions.