Abstract
Neutrophils are the main cellular component of the innate immune system, and defects in their functions will thus lead to increased susceptibility of infections. Essential for their function is their ability to adhere to the endothelial blood vessels and to migrate to site of infections. This chapter will discuss the various defects found in migration. Although, all these conditions are rare, some are more common. Leukocyte adhesion deficiency (LAD) type 1 has been reported in hundreds of patients worldwide, while some of the chemotaxis defects have been described in a single patient. For most of the syndromes the molecular defect has been revealed and thus a more appropriate approach to therapy can be given. In some cases the only curative treatment is hematopoietic stem cell transplantation while in other cases antibiotics alone can be enough. Recently, biological agents as well as gene therapy showed beneficial results in some cases.
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