Abstract
Multisystem atrophy (MSA) encompasses three clinicopathological conditions, either occurring singly or with variable degree of overlap and characterized by neuronal loss and gliosis in selective regions of the brain. Cytoplasmic inclusions referred to as (1) glial cytoplasmic inclusions, (2) oligodendroglial cytoplasmic inclusions, and (3) cytoplasmic microtubular tangles are now considered to be a histologic hallmark of these disorders and add a strong credibility to the concept proposed by earlier neuropathologists who grouped SND, OPCA, and SDS under the title of MSA. Oligodendroglial cytoplasmic inclusions are present in many regions of the cerebrum and cerebellum. In addition to these oligodendroglial inclusions, the neurons in certain regions of the brain display discrete intracytoplasmic inclusions.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
