Abstract
Publisher Summary This chapter discusses the formation of cross-species nerve connections in mouse hippocampal xenografts placed in the rat brain. The formation of nerve connections between the mouse fascia dentata and the host rat brain appears to be regulated by the same factors, which determines the exchange of host-graft connections in rat allograft studies. The chapter discusses conclusions on the basis of experimental findings: (1) surviving, intracerebral xenografts of mouse fascia dentata and hippocampus are organotypically organized and exchange nerve connections with the host rat brain to the same extent and according to the same principles as rat allografts; (2) complete structural integration in terms of merging of cell and neuropil layers and migration of host rat dentate granule cells into the mouse dentate xenografts is common after grafting to newborn recipients; and (3) the expression of species-specific cholecystokinin (CCK) immunoreactivity in mouse mossy fiber terminals with ingrowth into the host rat hippocampus provides a model for further studies of the developmental and functional interactions between defined groups of neurons.
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